D2 50,000 IU twice weekly provided the most rapid attainment and highest mean levels of vitamin D.Ģ5(OH)D = 25-hydroxyvitamin D BMI = body mass index BUN = blood urea nitrogen Ca/Cr = calcium/creatinine D2 = ergocalciferol D3 = cholecalciferol IU = international units PTH = parathyroid hormone. There was a negative correlation in mean PTH levels and mean vitamin D levels in group 4 and all groups combined.Īll four schedules of vitamin D replacement were effective in safely achieving and maintaining 25(OH)D >30 ng/mL (>75 nmol/L). Health and wellness Drug encyclopedia Print ergocalciferol (vitamin D2) 1,250 mcg (50,000 unit) capsule 9106 Medication name Uses How to use Side effects Precautions Drug interactions Overdose Notes Missed dose Storage Important note Information last revised March 2023. No episodes of significant hypercalcemia occurred. Although no statistically significant difference was seen in mean 25(OH)D levels between groups 1 through 3, subjects on 50,000 IU D2 weekly more consistently showed higher mean levels than either groups 1 or 2.
Those receiving 50,000 IU D2 twice weekly displayed the most rapid and robust response, with 25(OH)D reaching >30 ng/mL (>75 nmol/L) after only 1 month and plateauing at 60 ng/mL (150 nmol/L) by 7 months. D2, vitamin D2 D3, vitamin D3 IV, inverse variance 25(OH)D, 25-hydroxyvitamin D. In this prospective study, 100 subjects from the NY Harbor HCS Brooklyn Campus, ages 25 to 85 years, with 25(OH)D 30 ng/mL (>75 nmol/L) by visit 4 (5 months). One study chose a weekly intervention of 50,000 IU (17), and another.
To determine which vitamin D dose, formulation, and schedule most effectively and safely achieves a 25-hydroxyvitamin D (25D) level of >30 ng/mL (75 nmol/L).
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